Bifunctional compounds and use for reducing uric acid levels

A compound selected from the group consisting of

• a) compounds having a structure represented by Formula (I):
• wherein
• X is O or S;
• W is present or absent, and if present is one or more hydroxyl moieties, R1OH, or at least one hydroxyl moiety and R1OH;
• and
• Z is present or absent, and if present is SO2N(R2)2, —R1CO2H,
• —NR2SO2R3, —NR2SO2N(R2)2, or —NR2C(O)N(R2)2;
• wherein R1 is alkyl;
• wherein each R2 is independently H, alkyl or aryl, each optionally substituted with one or more halogen atoms or OR2;
• wherein each R3 is independently alkyl or aryl, each optionally substituted with one or more halogen atoms or OR2;
• and
• wherein each Xa is independently selected from either O or S,
• provided that at least one of W and Z is present, and if W is present and Z is absent, W is not 4′-hydroxy;
• b) compounds having a structure represented by Formula (II):
• wherein
• X is O or S;
• and
• each Z is independently present or absent and, if present, is independently selected from one or more halogen atoms, —CN, —CF3, —OR2, —C(O)R2, SR2, —S(O)fR3 where f is 1 or 2, —N(R2)2, —NO2, —CO2R2, —OCO2R3, OC(O)R2, —CON(R2)2, —NR2C(O)R2, —SO2(NR2)2, —NR2SO2R3, —NR2SO2N(R2)2, —NR2C(O)N(R2)2, alkyl, aryl, alkenyl and alkynyl;
• wherein each R2 is independently H, alkyl or aryl;
• wherein each R3 is independently alkyl or aryl, optionally substituted with one or more halogen atoms or OR2;
• and
• wherein a, b, c, d, and e are each independently carbon or nitrogen, with the proviso that at least one of a, b, c, d and e is nitrogen and Z is not connected directly to a nitrogen, except that Z may optionally be connected to a nitrogen at a, b, c, d, or e by replacement of the hydrogen of an NH group when Z is —C(O)R2, —S(O)fR3, —CO2R3, —CON(R2)2, —SO2N(R2)2, alkyl, aryl, alkenyl or alkynyl;
• c) compounds having a structure represented by Formula (III):
• wherein
• X is O or S;
• and
• each Z is independently present or absent and, if present, is independently selected from one or more halogen atoms, —CN, —CF3, —OR2, —C(O)R2, SR2, —S(O)fR3 where f is 1 or 2, —N(R2)2, —NO2, —CO2R2, —OCO2R3, OC(O)R2, —CON(R2)2, —NR2C(O)R2, —SO2(NR2)2, —NR2SO2R3, —NR2SO2N(R2)2, —NR2C(O)N(R2)2, alkyl, aryl, alkenyl and alkynyl;
• wherein each R2 is independently H, alkyl or aryl;
• wherein each R3 is independently alkyl or aryl, optionally substituted with one or more halogen atoms or OR2;
• and
• wherein a, b, and c, are each independently carbon or nitrogen, with the proviso that at least one of a, b, and c is nitrogen and Z is not connected directly to a nitrogen, except that Z may optionally be connected to a nitrogen at a, b, or c by replacement of the hydrogen of an NH group when Z is —C(O)R2, —S(O)fR3, —CO2R2, —CON(R2)2, —SO2N(R2)2, alkyl, aryl, alkenyl or alkynyl;
• and
• d) tautomers of any of the foregoing compounds.