Multitarget hedgehog pathway inhibitors and uses thereof

A method for the treatment of a Hedgehog (Hh)-dependent tumor pathology comprising:

• administering to a human subject needing inhibition of the Hedgehog (Hh)-dependent tumor pathology, an effective amount of the compound having general formula I,
• wherein:
• R1 is ORA;
• R2 is ORB;
• wherein each of RA and RB is hydrogen or acyclic branched or straight, saturated or unsaturated aliphatic chain having from 1 to 10 carbon atoms;
• R3 is ORC;
• and
• R4 is ORD;
• wherein each of RC and RD are methyl, ethyl, propyl, isopropyl, prenyl, geranyl, farnesyl or benzyl, wherein the phenyl of the benzyl group can be substituted by halogen, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 alkoxy, C1-C6 alkylthio, amino, C1-C6 alkylamino, or C1-C6 dialkylamino, wherein the compound is an antagonist of Gli1 and the effective amount inhibits activation of Gli1 associated with the Hh-pathway.