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US 10,093,641 B2Granted
Process for making beraprost
AssigneeUnited Therapeutics Corporation
InventorsHitesh Batra, Liang Guo
Life of this patent
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Abstract
A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.
Claims16
A process comprising:
- cyclizing a compound of formula (IV):
- to form a compound of formula (V):
- wherein R1a is a cation, H, or C1-12 alkyl;
- R2a is H or an hydroxy protective group;
- X is a halogen selected from chloro, bromo and iodo.
2 more elements
Dependencies are inferred from the claim text.