Back to results
US 10,093,632 B2Granted
Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine
AssigneeArQule, Inc.
InventorsCraig Bates, Jianmin Mao, David P. Reed
Life of this patent
Estimating the term…
Abstract
The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
Claims20
A method of making a polymorph of Compound A dihydrochloride salt:
- comprising Step 5a:
- step 5a-1) reacting Compound A:
- with an aqueous solution of HCl;
- and
- step 5a-4) adding acetone after the reaction between Compound A and HCl, in an amount to achieve a vol/vol ratio of acetone:water of about 95:5.
2 more elements
Dependencies are inferred from the claim text.