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US 10,093,629 B2Granted
Heterocyclic compounds and their use as retinoid-related orphan receptor (ROR) gamma-T inhibitors
AssigneeTakeda Pharmaceutical Company Limited
InventorsSatoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
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Abstract
Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Claims9
A compound represented by the following formula (I):
- wherein
- Ring A is an optionally further substituted 6-membered aromatic ring;
- R1 is
- (1) a group represented by the formula:
- —C(R1a)(CH3)(CH3) wherein R1a is an optionally substituted C1-6 alkoxy-C1-2 alkyl group, or R1a is bonded to one substituent on Ring A to form an optionally substituted 5-membered hydrocarbon ring, wherein the one substituent on Ring A is bonded to the position adjacent to the bonding position of R1 on Ring A, or
- (2) a trimethylsilyl group;
- R4 is an optionally substituted C3-6 cycloalkyl group;
- X is CR6 or N;
- R5 is an optionally substituted C1-6 alkyl group or an optionally substituted C1-6 alkoxy group;
- R6 is a hydrogen atom or a substituent;
- and
- when X is CR6, R5 and R6 in combination optionally form Ring D, wherein Ring D is an optionally substituted 5- or 6-membered oxygen-containing heterocycle containing 1 to 2 oxygen atoms as heteroatoms in addition to carbon atoms,
- or a salt thereof.
10 more elements
Dependencies are inferred from the claim text.