Competitive PPAR-gamma antagonists

A compound of the formula (I), or a stereoisomer, or salt thereof:

• wherein
• R1 is selected from a non-substituted, monosubstituted or polysubstituted aryl or heteroaryl residue,
• R2 is a radical of the formula (III),
• wherein
• X and Z are independently selected from C or N,
• R9 to R12 are independently selected from H, hydroxyl, a non-substituted, monosubstituted or polysubstituted C1-C18-alkyl, wherein the alkyl can be straight, branched or cyclic, alkenyl, trifluormethyl, a non-substituted, monosubstituted or polysubstituted aryl or heteroaryl residue, a non-substituted, monosubstituted or polysubstituted benzyl group, an acyl group, or a branched or heteroatom- or aryl-substituted acyl group, an alkoxy substituent, the alkyl group thereof is branched, non-branched or cyclic, an alkyl group bound through a sulfur atom, or a sulfonyl group, or a nitrogen substituent, or fluoro, chloro, bromo, iodo, —CN or a hetero substituent, if X is N then R11 is absent, and if Z is N then R12 is absent;
• and
• R1 and R2 are different, and
• R3 is a non-substituted, monosubstituted or polysubstituted C1-C10-alkyl, wherein the alkyl can be straight, branched or cyclic.