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US 10,093,622 B2Granted
Efficient process for the synthesis of cyclic amides
AssigneeAnthea Aromatics Private Limited
InventorsManoj Kumar Mohapatra, Ramamohanrao Bendapudi, Paul Vincent Menacherry, Vincent Paul
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Abstract
Disclosed herein is an efficient, economical, industrially advantageous, straight-through process for the preparation of cyclic amides, also referred as lactams, in substantially pure form and high yield, from the corresponding cyclic ketones and a hydroxylammonium salt, using a combination of amphoteric metal oxide or amphoteric masked metal oxide and a base.
Claims10
A process for the preparation of cyclic amides of Formula I:
- comprising the steps of
- a) contacting a compound of Formula II
- with a hydroxylammonium salt, amphoteric metal oxide and a base for in-situ preparation of corresponding compound of Formula X;
- b) removing water formed;
- and
- c) contacting the compound of Formula X with a rearrangement solvent and a metal salt formed insitu as a by-product during formation of the compound of Formula X to catalyse a rearrangement reaction resulting into formation of the cyclic amide Formula I;
- wherein
- R1, R2, R3 and R4 are hydrogen,
- n is 1, and
- m is 8.
7 more elements
Dependencies are inferred from the claim text.