Benzocycloalkenes as antifungal agents

A compound of formula (II)

• wherein
• n represents 0 or 1;
• L1 represents CZ1Z2, NZ7, O, S, S(O) or S(O)2;
• L2, L3 and L4 independently represents a direct bond, CZ1Z2, NZ7, O, S, S(O) or S(O)2;
• providing that when L2 represents NZ7, O, S, S(O) or S(O)2 then L3, L4 independently represent a direct bond or CZ1Z2;
• or
• providing that when L3 represents NZ7, O, S, S(O) or S(O)2 then L2 represent CZ1Z2 and L4 represent direct bond or CZ1Z2;
• or
• providing that when L4 represents NZ7, O, S, S(O) or S(O)2 then L2, L3 independently represent CZ1Z2;
• m represents 0, 1, 2 or 3;
• X represents a halogen atom;
• nitro;
• cyano;
• isonitrile;
• hydroxy;
• amino;
• sulfanyl;
• pentafluoro-λ6-sulfanyl;
• formyl;
• formyloxy;
• formylamino;
• substituted or non-substituted (hydroxyimino)-C1-C8-alkyl;
• substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl;
• substituted or non-substituted (C2-C8-alkenyloxyimino)-C1-C8-alkyl;
• substituted or non-substituted (C2-C8-alkynyloxyimino)-C1-C8-alkyl;
• substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl;
• carboxy;
• carbamoyl;
• N-hydroxycarbamoyl;
• carbamate;
• substituted or non-substituted C1-C8-alkyl;
• C1-C8-halogenoalkyl having 1 to 5 halogen atoms;
• substituted or non-substituted C2-C8-alkenyl;
• C2-C8-halogenoalkenyl having 1 to 5 halogen atoms;
• substituted or non-substituted C2-C8-alkynyl;
• C2-C8-halogenoalkynyl having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkoxy;
• C1-C8-halogenoalkoxy having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkylsulfanyl;
• C1-C8-halogenoalkylsulfanyl having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkylsulfinyl;
• C1-C8-halogenoalkylsulfinyl having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkylsulfonyl;
• C1-C8-halogenoalkylsulfonyl having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkylamino;
• substituted or non-substituted di-C1-C8-alkylamino;
• substituted or non-substituted C2-C8-alkenyloxy;
• C2-C8-halogenoalkenyloxy having 1 to 5 halogen atoms;
• substituted or non-substituted C3-C8-alkynyloxy;
• C2-C8-halogenoalkynyloxy having 1 to 5 halogen atoms;
• substituted or non-substituted C3-C7-cycloalkyl;
• C3-C7-halogenocycloalkyl having 1 to 5 halogen atoms;
• substituted or non-substituted (C3-C7-cycloalkyl)-C1-C8-alkyl;
• substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkenyl;
• substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkynyl;
• substituted or non-substituted tri(C1-C8)alkylsilyl;
• substituted or non-substituted tri(C1-C8)alkylsilyl-C1-C8-alkyl;
• substituted or non-substituted C1-C8-alkylcarbonyl;
• C1-C8-halogenoalkylcarbonyl having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkylcarbonyloxy;
• C1-C8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkylcarbonylamino;
• C1-C8-halogenoalkyl-carbonylamino having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkoxycarbonyl;
• C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkyloxycarbonyloxy;
• C1-C8-halogenoalkoxycarbonyloxy having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkylcarbamoyl;
• substituted or non-substituted di-C1-C8-alkylcarbamoyl;
• substituted or non-substituted C1-C8-alkylaminocarbonyloxy;
• substituted or non-substituted di-C1-C8-alkylaminocarbonyloxy;
• substituted or non-substituted N—(C1-C8-alkyl)hydroxy carbamoyl;
• substituted or non-substituted C1-C8-alkoxycarbamoyl;
• substituted or non-substituted N—(C1-C8-alkyl)-C1-C8-alkoxycarbamoyl;
• aryl that can be substituted by up to 6 groups Q which can be the same or different;
• C1-C8-arylalkyl that can be substituted by up to 6 groups Q which can be the same or different;
• C2-C8-arylalkenyl that can be substituted by up to 6 groups Q which can be the same or different;
• C2-C8-arylalkynyl that can be substituted by up to 6 groups Q which can be the same or different;
• aryloxy that can be substituted by up to 6 groups Q which can be the same or different;
• arylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different;
• arylamino that can be substituted by up to 6 groups Q which can be the same or different;
• C1-C8-arylalkyloxy that can be substituted by up to 6 groups Q which can be the same or different;
• C1-C8-arylalkylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different;
• or C1-C8-arylalkylamino that can be substituted by up to 6 groups Q which can be the same or different;
• two substituent X together with the consecutive carbon atoms to which they are linked can form a 5- or 6-membered, saturated carbocycle or saturated heterocycle, which can be substituted by up to four groups Q which can be the same or different;
• Z1, Z2, Z3, Z4 and Z5 independently represents a hydrogen atom;
• halogen atom;
• cyano;
• substituted or non-substituted C1-C8-alkyl;
• C1-C8-halogenoalkyl having 1 to 5 halogen atoms;
• substituted or non-substituted C1-C8-alkoxy;
• substituted or non-substituted C1-C8-alkylsulfanyl;
• or substituted or non-substituted C1-C8-alkoxycarbonyl;
• or Z4 and Z5 are a C2-C5-alkylene group that can be substituted by up to four C1-C8-alkyl groups;
• and Z6 represents a cyclopropyl group with the exclusion of
• substituted N-cyclopropyl-1,2,3,4-tetrahydronaphthalen-2-amines,
• substituted N-cyclopropylchroman-3-amines,
• N-cyclopropyl-2,3-dihydro-1H-inden-2-amine,
• N-(3,4-dihydro-2H-chromen-3-ylmethyl)cyclopropanamine,
• N-(2,3-dihydro-1-benzofuran-2-ylmethyl)cyclopropanamine.