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US 10,092,903 B2Granted
Multi-compartment device with magnetic particles
AssigneeKoninklijke Philips N.V.
InventorsMenno Willem Jose Prins, Joost Hubert Maas, Albert Hendrik Jan Immink, Dirkjan Bernhard Van Dam, Maatje Koets, Michel J. M. Bruyninckx, Thea Van Der Wijk, Marius Iosif Boamfa, Remco Den Dulk
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Abstract
The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
Claims11
A device for transferring magnetic particles in a fluidic sample, the device comprising:
- first and second substrates forming, therebetween, two compartments and a channel interconnecting the two compartments;
- and
- a valve-like structure that allows passage of the magnetic particles through the channel between the two compartments upon application of a magnetic force to the magnetic particles, wherein
- the valve-like structure comprises a hydrophobic barrier formed by a silane hydrophobic surface in the channel that prevents a fluid disposed in one of the two compartments from migrating to the other of the two compartments in the absence of a magnetic force acting upon the magnetic particles.
1 more element
A device for transferring magnetic particles in a fluidic sample, the device comprising:
- first and second substrates situated apart from each other and mirroring each other to form two compartments and a channel interconnecting the two compartments, one of the two compartments is configured to include the magnetic particles, and
- a valve-like structure that allows passage of the magnetic particles through the channel between the two compartments upon application of a magnetic force to the magnetic particles, wherein
- the valve-like structure comprises a hydrophobic barrier formed by a silane hydrophobic surface in the channel that prevents a fluid disposed in the one compartment from migrating to the other of the two compartments in the absence of the magnetic force acting upon the magnetic particles.
Dependencies are inferred from the claim text.