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US 10,092,750 B2Granted
Transcutaneous neuromodulation system and methods of using same
AssigneeNeuroenabling Technologies, Inc.
InventorsVictor Reggie Edgerton, Yury P. Gerasimenko, Nicholas A. Terrafranca, Parag Gad
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Abstract
Neuromodulation systems are described comprising a signal generator and at least one electrode. The at least one electrode can be configured to deliver a stimulation to a mammal, wherein the stimulation includes a biphasic signal and an overlapping high frequency pulse thereby inducing voluntary movement in the individual. Methods of administering the stimulation are also described.
Claims20
A neuromodulation system comprising:
- a processor;
- a signal generator;
- and
- at least one electrode;
- wherein the processor, in cooperation with the signal generator and the at least one electrode are configured to deliver a first transcutaneous stimulation to a spinal cord or brainstem of a mammal, the stimulation including first parameters defining a signal and an overlapping high frequency pulse, the first transcutaneous stimulation configured to induce voluntary movement in the mammal,
- the system further comprising one or more sensors configured to measure a response of the mammal related to the first transcutaneous stimulation,
- wherein the processor is configured to determine a second transcutaneous stimulation having second parameters by performing a Gaussian process optimization or a dueling bandit machine learning algorithm or process that is configured to use, in part, an association between the measured response and the first parameters of the first transcutaneous stimulation.
4 more elements
A method of inducing a voluntary movement in a mammal with a spinal injury, the method comprising:
- delivering, using a transcutaneous neuromodulation system, a first transcutaneous stimulation to a spinal cord or brainstem of the mammal, the first transcutaneous stimulation including first parameters defining a signal and an overlapping high frequency pulse;
- measuring, via a sensor, a response of the mammal related to the first transcutaneous stimulation;
- determining a second transcutaneous stimulation including second parameters using a processor by performing a Gaussian process optimization or a dueling bandit machine learning algorithm or process that is configured to use, in part, an association between the measured response and the first parameters of the first transcutaneous stimulation, and
- applying the second transcutaneous stimulation to the spinal cord or brainstem of the mammal using the transcutaneous neuromodulation system.
1 more element
Dependencies are inferred from the claim text.