Biohybrid composite scaffold
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsNicholas J. Amoroso, Stephen Francis Badylak, Yi Hong, Alexander Huber, Keisuke Takanari, William R. Wagner
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Abstract
A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
Claims20
A biohybrid scaffold comprising a matrix of a biodegradable, biocompatible elastomeric polymer and an ECM-derived gel interspersed substantially evenly throughout the matrix, wherein
- the ECM-derived gel composition is prepared by:
- (i) solubilizing decellularized tissue that has not been dialyzed by digestion with an acid protease, thereby producing a digest solution;
- and (ii) raising the pH of the digest solution to between 7.2 and 7.8.
A method of growing tissue in a patient comprising implanting a biohybrid scaffold comprising a matrix of a biodegradable, biocompatible elastomeric polymer and an ECM-derived gel interspersed substantially evenly throughout the matrix in a patient at a site of injury or defect in the patient, wherein
- the ECM-derived gel composition is prepared by:
- (i) solubilizing decellularized tissue that has not been dialyzed by digestion with an acid protease, thereby producing a digest solution;
- and (ii) raising the pH of the digest solution to between 7.2 and 7.8.
A biohybrid scaffold comprising:
- a matrix of a biodegradable, biocompatible elastomeric polymer;
- an ECM-derived gel interspersed substantially evenly throughout the matrix;
- and
- one or more layers of a wet-electrospun biodegradable, biocompatible elastomeric polymer attached to the matrix of a biodegradable, biocompatible elastomeric polymer and the ECM-derived gel interspersed substantially evenly throughout the matrix, forming a composite scaffold structure.
A method of growing tissue in a patient comprising:
- implanting in a patient at a site of injury or defect in the patient a biohybrid scaffold comprising:
- a matrix of a biodegradable, biocompatible elastomeric polymer;
- an ECM-derived gel interspersed substantially evenly throughout the matrix;
- and
- one or more layers of a wet-electrospun biodegradable, biocompatible elastomeric polymer attached to the matrix of a biodegradable, biocompatible elastomeric polymer and the ECM-derived gel interspersed substantially evenly throughout the matrix, forming a composite scaffold structure.
Dependencies are inferred from the claim text.