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US 10,092,660 B2Granted
Solid compositions for pharmaceutical use
AssigneeStc.Unm
InventorsHugh Smyth, Ibrahim M. El-Sherbiny
Life of this patent
Estimating the term…
Abstract
The invention relates to solid compositions that may be suitable for administering a therapeutic agent to a subject. The invention also relates to methods of making such solid compositions. The invention further relates to methods of treating a disease, condition, or disorder by administering to a subject such solid compositions.
Claims30
A solid composition comprising a plurality of hydrogel particles, wherein the hydrogel particles each comprise:
- hydrophilic polymer molecules;
- and
- a pharmacologically-active agent that treats a disease, disorder, or condition when administered into a subject, the pharmacologically-active agent comprising one or more of amikacin, ciprofloxacin, streptomycin, rifampicin, isoniazid, ethambutol, pyrazinamide, ibuprofen, tobramycin, epinephrine, salbutamol, salmeterol, clenbuterol, levalbuterol, or a pharmaceutically acceptable salt thereof, wherein molecules of the pharmacologically-active agent non-covalently chemically bond with two or more of the hydrophilic polymer molecules to form non-covalent chemical crosslinking between the hydrophilic polymer molecules sufficient to form a hydrophilic polymer matrix without the use of other crosslinking agents.
A solid composition comprising a plurality of hydrogel particles, wherein the hydrogel particles each comprise:
- a plurality of hydrophilic polymer molecules;
- and
- a pharmacologically-active agent that treats a disease, disorder, or condition when administered into a subject, the pharmacologically-active agent comprising at least one of ciprofloxacin, tobramycin, or a pharmaceutically acceptable salt thereof, wherein molecules of the pharmacologically-active agent non-covalently chemically bond with two or more of the hydrophilic polymer molecules to form non-covalent chemical crosslinking between the two or more hydrophilic polymer molecules sufficient to form a hydrophilic polymer matrix without the use of other crosslinking agents.
Dependencies are inferred from the claim text.