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US 10,092,654 B2Granted
Coacervate micro and/or nano droplets and hydrogels
AssigneeCase Western Reserve University
InventorsEben Alsberg, Oju Jeon, David Wolfson
Life of this patent
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Abstract
A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.
Claims18
A composition comprising:
- a plurality of coacervate microdroplets and/or nanodroplets that include an oxidized alginate and a methacrylated gelatin, and at least one bioactive agent incorporated in the plurality of coacervate microdroplets and/or nanodroplets, wherein the oxidized alginate has an oxidation percentage of at least 10% of uronic acid units of alginate and the methacrylated gelatin has a methacrylation percentage of about 10% to about 99% of amine groups of gelatin.
A coacervate hydrogel comprising:
- crosslinked oxidized alginate and methacrylated gelatin that form a hydrogel matrix and a plurality of coacervate microdroplets and/or nanodroplets suspended in the matrix, wherein the oxidized alginate has an oxidation percentage of at least 10% of uronic acid units of alginate and the methacrylated gelatin has a methacrylation percentage of about 10% to about 99% of amine groups of gelatin.
A coacervate hydrogel comprising:
- a crosslinked oxidized methacrylated alginate and a methacrylated gelatin that form a hydrogel matrix and a plurality of coacervate microdroplets and/or nanodroplets, wherein the oxidized methacrylated alginate has an oxidation percentage of 10% up to 50% of uronic acid units and a methacrylation percentage up to 45% of carboxylic acid reactive groups of alginate, the methacrylated gelatin has a methacrylation percentage of at least about 10% to about 99% of amine groups of alginate.
Dependencies are inferred from the claim text.