Polytetrafluoroethylene co-polymer emulsions
AssigneeW. L. Gore & Associates, Inc.
InventorsRobert L. Cleek, Edward H. Cully, Paul D. Drumheller, Theresa A. Holland
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
Claims11
A coating consisting of:
- a tetrafluoroethylene copolymer;
- and
- dexamethasone sodium phosphate,
- wherein the coating is formed by applying a kinetically stable emulsion consisting of a tetrafluoroethylene copolymer dissolved in a water miscible organic solvent and dexamethasone sodium phosphate dissolved in water, and removing the water miscible organic solvent and water, and
- wherein the coating has a weight percentage of dexamethasone sodium phosphate of 69% by mass, and at least a 50% reduction in excess heat capacity on a tetrafluoroethylene copolymer mass basis as compared with a coating of tetrafluoroethylene copolymer with no dexamethasone sodium phosphate, and wherein the polytetrafluoroethylene copolymer is poly(tetrafluoroethylene-co-vinyl acetate) (TFE-VAc).
A coating consisting of:
- a tetrafluoroethylene copolymer;
- and
- dexamethasone sodium phosphate,
- wherein the coating is formed by applying a kinetically stable emulsion consisting of a tetrafluoroethylene copolymer dissolved in a water miscible organic solvent and dexamethasone sodium phosphate dissolved in water, and removing the water miscible organic solvent and water, and
- wherein the coating has a weight percentage of dexamethasone sodium phosphate of 69% by mass, wherein the emulsion is phase mixed as measured by modulated differential scanning calorimetry, and wherein the polytetrafluoroethylene copolymer is poly(tetrafluoroethylene-co-vinyl acetate) (TFE-VAc).
A coating for a medical device, the coating consisting of the following components:
- a tetrafluoroethylene copolymer;
- and
- dexamethasone sodium phosphate,
- wherein the coating is formed by applying a kinetically stable emulsion consisting of a tetrafluoroethylene copolymer dissolved in a water miscible organic solvent and dexamethasone sodium phosphate dissolved in water, and removing the water miscible organic solvent and water, and
- wherein the coating has a weight percentage of dexamethasone sodium phosphate of 69% by mass, and shows no reversing exotherms on a tetrafluoroethylene copolymer mass basis and decreased non-reversing exotherms on a tetrafluoroethylene copolymer mass basis in a first heating run from a low temperature of −20° C. to a high temperature of 100° C. as measured by modulated differential scanning calorimetry, and wherein the polytetrafluoroethylene copolymer is poly(tetrafluoroethylene-co-vinyl acetate) (TFE-VAc).
A coating consisting of:
- poly(tetrafluoroethylene-co-vinyl acetate) (TFE-VAc), and
- 69% by mass dexamethasone sodium phosphate,
- wherein the coating is formed by applying a kinetically stable emulsion consisting of a tetrafluoroethylene copolymer dissolved in a water miscible organic solvent and dexamethasone sodium phosphate dissolved in water, and removing the water miscible organic solvent and water, and
- wherein the emulsion is phase mixed as measured by modulated differential scanning calorimetry.
Dependencies are inferred from the claim text.