Guided bone regeneration membrane and manufacturing method thereof
AssigneesNational University Corporation Nagoya Institute of Technology, Yabashi Industries Co., Ltd., Yamahachi Dental Mfg., Co., Orthorebirth Co., Ltd.
InventorsToshihiro Kasuga, Yoshio Ota, Takashi Wakita
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Abstract
A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electrospinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability.
Claims8
A method for producing a fibrous biodegradable bone regeneration material by using an electrospinning process, comprising:
- kneading a mixture of biodegradable polymer by using a kneader to produce a composite, wherein the mixture comprises a biodegradable polymer and silicon-releasing calcium carbonate particles, and wherein a content of the silicon-releasing calcium carbonate particles in the composite is 40 to 60 wt %;
- dissolving the composite in chloroform having a purity of 99% or more to produce a spinning solution having a polymer content of 4 to 12 wt %;
- feeding the spinning solution to a nozzle of an electrospinning apparatus at a predetermined rate;
- spinning a biodegradable fiber from the nozzle toward a collector of the electrospinning apparatus by applying a high voltage to the nozzle to convert the spinning solution into the biodegradable fiber in an electric field between the nozzle and the collector while evaporating the chloroform;
- and
- collecting the fiber deposited on the collector.
Dependencies are inferred from the claim text.