Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy

A method of treating cancer in a patient comprising

• a. administering to the patient a fraction of fractionated radiation therapy;
• and
• b. administering to the patient at least one PD-1 and/or PD-L1 antagonist, wherein the at least one PD-1 and/or PD-L1 antagonist is administered on the same day as the fraction of radiation therapy or up to and including 4 days later, wherein the fraction is 2.2 Gy or lower, and wherein the cancer is bladder cancer, breast cancer, colorectal cancer, head and neck cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer or renal cancer.