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US 10,092,644 B2Granted
Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants
AssigneesBrock University, National Research Council of Canada
InventorsHongbin Yan, Wangxue Chen, Rhonda Kuo Lee
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Abstract
Disclosed is the use of fluorinated cyclic dinucleotides and pharmaceutically acceptable salts thereof as an adjuvant for the preparation of an oral vaccine. Further disclosed is the use of fluorinated cyclic dinucleotides and pharmaceutically acceptable salts thereof for enhancing the immune response to an orally administered vaccine.
Claims10
A method for enhancing an immune response to an administered vaccine, comprising:
- administering a vaccine with an effective amount of an adjuvant comprising a fluorinated cyclic dinucleotide or a pharmaceutically acceptable salt thereof, wherein the fluorinated cyclic dinucleotide has the following structure:
- wherein A, C, A′ and C′ are independently selected from NH, O or S;
- X, Y, X′, and Y′ are independently selected from O or S;
- Z and Z′ are independently selected from O, S, NH or CH2;
- and B1 and B2 are independently a purine selected from:
- wherein Q is hydrogen or NH2;
- nitrogen is optionally substituted with C1-C6 alkyl or C1-C6 acyl group;
- and R is O or S.
5 more elements
Dependencies are inferred from the claim text.