Prophylactic and immunomodulatory compositions and uses
AssigneeKherion Technology Limited
InventorMarc Creus
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Abstract
Provided is use of a sphingosine compound, or a derivative of a sphingosine compound, in the manufacture of a vaccine effective in the treatment and prevention of an infectious disease and treatment and/or prevention of an autoimmune disease. Also provided is use of a sphingosine compound, or a derivative of a sphingosine compound, in the manufacture of an immunomodulation medicament effective in the prevention of infectious disease and treatment and/or prevention of an autoimmune disease.
Claims10
A method to treat a subject suffering from an autoimmune disease, the method comprising injecting into the subject a composition comprising sphingosine-1-phosphate (SIP) or a salt thereof, as the sole active ingredient and at a concentration from 1 to 200 microM, wherein the autoimmune disease is Crohn's disease, sarcoidosis, or inflammatory bowel disease (IBD), and wherein the concentration of the S1P is effective to reduce chronic inflammation while promoting an immune response, thereby treating the autoimmune disease.
Dependencies are inferred from the claim text.