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AssigneePerosphere Technologies Inc.
InventorsBryan E. Laulicht, Sasha H. Bakhru, Solomon S. Steiner, Edith Mathiowitz
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Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system. In preferred embodiments, the compositions are administered to yield therapeutically effective levels of antigen within the lymph, where macrophages reside in the greatest concentration, by intradermal administration, using for example, microneedles or micro articles, oral administration, using for example, enteric coated capsules or tablets, or autologous transfusion. In some embodiments, the methods and compositions for delivering antigens orally achieve uptake by the Peyer's patches of the small intestines.
A method for selective delivery to the lymphatic system comprising administering by intradermal injection of microparticles comprising one or more antigens through a hollow microneedles, the microparticles having a mean equivalent circle diameter in the range of one to ten microns and comprising chitosan or a chitosan derivative, that is an enzymatically cleavable polymer that is sensitive to degradation by macrophage lysozomal enzymes, the microparticles to be delivered to the cells in the lymph system, wherein less than twenty-five percent of the one or more antigens is released within forty eight hours after administration prior to uptake by macrophages, wherein the microparticles further comprise a net charge altering agent to promote macrophage engulfment and wherein the net charge altering agent is one or a combination of charged amino acids.
Dependencies are inferred from the claim text.