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US 10,092,636 B2Granted
Vectors for expression of prostate-associated antigens
AssigneePfizer Inc.
InventorJoseph John Binder
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Abstract
The present disclosure provides (a) vectors comprising a multi-antigen construct encoding two, three, or more immunogenic PAA polypeptides; (b) compositions comprising the vectors, (c) methods relating to uses of the vectors and compositions for eliciting an immune response or for treating prostate cancers.
Claims14
A C68 vector, comprising:
- (1) a C68 nucleotide sequence;
- and
- (2) a multi-antigen construct comprising two coding nucleotide sequences, wherein the C68 nucleotide sequence is the sequence of SEQ ID NO:
- 57 lacking at least one gene selected from the group consisting of E1A, E1B, E2A, E2B, E3, E4, L1, L2, L3, L4 and L5 genes, wherein the two coding nucleotide sequences encode two different immunogenic PAA polypeptides selected from the group consisting of:
- (1) an immunogenic PSMA polypeptide and an immunogenic PSA polypeptide;
- and
- (2) an immunogenic PSA polypeptide and an immunogenic PSCA polypeptide, and
- wherein the immunogenic PSA polypeptide comprises an amino acid sequence selected from the group consisting of:
- (1) an amino acid sequence comprising amino acids 27-263 of SEQ ID NO:15;
- (2) an amino acid sequence comprising amino acids 4-240 of SEQ ID NO:17;
- and
- (3) the amino acid sequence of SEQ ID NO:17.
9 more elements
Dependencies are inferred from the claim text.