Tumor vaccines and methods of use thereof
AssigneeUniversity of Iowa Research Foundation
InventorsTony Vanden Bush, Gail Bishop
Life of this patent
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Abstract
The present invention provides a therapeutic agent comprising an antibody-recognition epitope (ARE) covalently bound to a tumor cell, wherein the ARE is bound to an antibody that is specific for the ARE, to form a tumor cell:ARE:antibody complex, and kits and methods of using these tumor cell:ARE:antibody complexes.
Claims5
A method of treating a disease or disorder arising from abnormal cell growth, function or behavior, which method comprises administering to a patient in need thereof a therapeutic agent comprising an antibody-recognition epitope (ARE) comprising an antibody-recognition epitope (ARE) comprising a VP-1 epitope of polio, chemically conjugated to a tumor cell, wherein the VP-1 epitope of polio of is about 18-28 amino acids in length and comprises IPALTAVETGA (SEQ ID NO:
- 1), AHSKEIPALTAVETGATA (SEQ ID NO:
- 2) or ALTAVETGAT (SEQ ID NO:
- 3), and wherein the ARE is bound to an antibody that is specific for the ARE, to form a tumor cell:ARE:antibody complex.
Dependencies are inferred from the claim text.