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AssigneeNestec S.A.
InventorsCarine Blanchard, Sophie Nutten, Alexandre Panchaud
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The invention relates to newly identified peptides of that are capable of inducing tolerance to cow's milk, especially to β-lactoglobulin. The peptides may be administered to mammals, especially to young infants who are at risk of allergy to cow's milk proteins, to induce oral tolerance to cow's milk; they may also be administered to children or adults who are allergic to cow's milk to allow “desensitization” towards the allergenic milk proteins, especially β-lactoglobulin, to occur. The peptides may also be used to induce tolerance to goat's and buffalo's milk proteins, especially β-lactoglobulin. The peptides are capable of modulating the mammalian immune response to allergens.
A method for inducing oral tolerance to a milk protein from at least one of cow, sheep, buffalo or goat in a mammal, the method comprising administering to the mammal at least one peptide having an amino acid length from five to twelve amino acids and comprising a sequence selected from the group consisting of SEQ ID No. 1-5, the at least one peptide is administered at a dose between 0.4-50 μmol/per kg bodymass/day.
A method for inducing oral tolerance to cow's, buffalo's or goat's milk proteins in a mammal, the method comprising administering to the mammal a composition comprising at least one peptide selected from the group of sequences consisting of SEQ ID No. 1-5, the at least one peptide is administered at a dose between 0.4-50 μmol/per kg bodymass/day.
Dependencies are inferred from the claim text.