Methods of treating anorexia nervosa by intranasal administration of insulin
AssigneeHealthPartners Institute
InventorWilliam H. Frey, II
Life of this patent
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Abstract
The present system is directed in several embodiments to a method of administration of a therapeutic composition for treatment of Anorexia Nervosa, safely and without significantly affecting the blood glucose or blood insulin levels of the patient. The method includes administering one or more therapeutic compositions comprising an effective amount of insulin directly to the subject patient's CNS, with no to minimal systemic exposure. Preferably, this method comprises administration of an effective amount of insulin to the upper third of a patient's nasal cavity, thereby bypassing the patient's blood-brain barrier and delivering the therapeutic composition directly to the patient's central nervous system.
Claims19
A method for treating Anorexia Nervosa in a patient that has blood glucose and blood insulin levels within normal limits, comprising:
- administering at least an effective amount of insulin to the upper third of the nasal cavity of the patient;
- enabling at least an effective amount of insulin to directly access the patient's central nervous system by bypassing the blood-brain barrier;
- and
- treating the patient's Anorexia Nervosa while not altering the patient's systemic non-CNS blood glucose or blood insulin to unsafe levels, outside the normal limits.
A method of treating a patient with Anorexia Nervosa having blood glucose and/or blood insulin levels that are not within normal limits, comprising:
- administering at least an effective amount of insulin to the upper third of the nasal cavity of the patient;
- enabling at least an effective amount of insulin to directly access the patient's central nervous system by bypassing the blood-brain barrier;
- and
- safely treating the patient's Anorexia Nervosa without significantly affecting the patient's systemic non-CNS blood glucose or insulin levels.
Dependencies are inferred from the claim text.