Treating cardiovascular or renal diseases
AssigneeMayo Foundation for Medical Education and Research
InventorsYasuhiro Ikeda, Stephen James Russell, Alessandro Cataliotti, John C. Burnett, Jr., Jason M. Tonne
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Abstract
This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic polypeptides, nucleic acid molecules encoding natriuretic polypeptides, methods for making AAV9 vectors, and methods for using such vectors or molecules to treat cardiovascular and/or renal diseases are provided.
Claims6
A method for improving cardiac function in a mammal with polycystic kidney disease, wherein said method comprises administering an AAV8 vector to said mammal with polycystic kidney disease,
- wherein said AAV8 vector comprises a nucleic acid sequence encoding a natriuretic polypeptide, and
- wherein cardiac function is improved at least two months following said administration when said AAV8 vector is administered to said mammal with polycystic kidney disease.
Dependencies are inferred from the claim text.