Occidiofungin, a unique antifungal glycopeptide produced by a strain of Burkholderia contaminans
AssigneeMississippi State University
InventorsShien Lu, James L. Smith, Frank Austin, Ganyu Gu
Life of this patent
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Abstract
The present invention is directed to novel antifungal glycopeptide compounds and salts thereof produced by a strain of Burkholderia contaminans useful for preventing or treating fungal infection or disease in animals and plants and the bacterial strain that produces the compounds.
Claims15
A method of treating a cell walled pathogen in a subject in need thereof, comprising:
- administering to the subject in need thereof an antifungal cyclic glycopeptide compound selected from the group consisting of occidiofungin A and occidiofungin B;
- wherein the antifungal cyclic glycopeptide compound is administered in a therapeutically effective amount sufficient to inhibit growth of the cell walled pathogen;
- wherein the cell walled pathogen is selected from the group consisting of an oomycotes pathogen and a fungal pathogen;
- and wherein the oomycotes pathogen is selected from the list consisting of Pythium spinosum and Pythium ultimum and the fungal pathogen selected from the list consisting of Alternaria alternate, Aspergillus fumigatus, Aspergillus niger, Fusarium oxysporum, Geotrichum candidum, Candida albicans, Macrophomina phaseolina, Microsporum gypseum, Penicillium sp., Rhizoctonia solani, and Trichophyton mentagrophytes.
A method of disrupting membrane integrity in a cell walled pathogen by administering to a subject in need thereof an antifungal cyclic glycopeptide compound selected from the group consisting of occidiofungin A and occidiofungin B;
- wherein the cell walled pathogen is selected from the group consisting of an oomycotes pathogen and a fungal pathogen;
- and wherein the oomycotes pathogen is selected form the list consisting of Pythium spinosum and Pythium ultimum and the fungal pathogen selected from the list consisting of Alternaria alternate, Aspergillus fumigatus, Asperigillus niger, Fusarium oxysporum, Geotrichum candidum, Candida albicans, Macrophomina phaseolina, Microsporum gypseum, Penicillium sp., Rhizoctonia solani, and Trichophyton mentagrophytes.
Dependencies are inferred from the claim text.