Effects of a decaffeinated green coffee extract on body weight control by regulation of glucose metabolism
AssigneeNaturex, S.A.
InventorsAlvin Ibarra, Marc Roller, Jacques Dikansky
Life of this patent
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Abstract
A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.
Claims19
A method of inhibiting human liver glucose-6-phosphatase system (Glc-6-Pase system) activity, the method comprising administering to an overweight human subject, or a human subject having obesity or type 2 diabetes an amount of green coffee extract obtained from Coffea robusta effective to inhibit the human liver Glc-6-Pase activity;
- wherein
- said green coffee extract comprises, by weight of said green coffee extract, from about 6% to about 8% of 4-CQA and more than 45% of total chlorogenic acids (tCGA);
- and
- said 4-CQA is present in a weight ratio of from about 0.1 to about 0.2 with respect to said total chlorogenic acids (tCGA).
A method of inhibiting human liver glucose-6-phosphatase system (Glc-6-Pase) activity, the method comprising administering to an overweight human subject, or a human subject having obesity or type 2 diabetes an amount of green coffee extract obtained from Coffea robusta effective to inhibit the human liver Glc-6-Pase activity;
- wherein said green coffee extract comprises, by weight of said green coffee extract:
- from about 6% to about 8% of 4-caffeoylquinic acid;
- from about 13% to about 16% of 5-caffeoylquinic acid;
- from about 2% to about 5% of 3,4-dicaffeoylquinic acid;
- and
- from about 3% to about 5% of 4,5-dicaffeoylquinic acid.
Dependencies are inferred from the claim text.