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US 10,092,602 B2Granted
Elastic tissue matrix derived hydrogel
AssigneeLifeCell Corporation
InventorsWenquan Sun, Hui Xu, Hua Wan
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Abstract
A tissue-derived hydrogel, as well as methods of making and using such hydrogels, are provided.
Claims13
A tissue-derived hydrogel comprising:
- an acellular arterial tissue matrix that has been treated with an elastase at a concentration of between 0.021 and 5.35 units per ml for 5 to 96 hours to form a hydrogel, wherein the hydrogel comprises a swollen and softened arterial tissue matrix having a disrupted elastin network, and wherein the hydrogel comprises a moldable putty that will conform to the shape of a space in which it is implanted, and possesses increased malleability after the elastase treatment as compared to the acellular tissue matrix from which the hydrogel is formed.
A method of preparing a tissue-derived hydrogel, comprising:
- harvesting an arterial tissue;
- decellularizing the tissue;
- and
- treating the arterial tissue with an elastase at a concentration of between 0.021 and 5.35 units per ml for 5 to 96 hours to produce a hydrogel comprising a swollen and softened arterial tissue matrix having a disrupted elastin network, and wherein the hydrogel comprises a moldable putty that will conform to the shape of a space in which it is implanted, and wherein the hydrogel possesses increased malleability after the elastase treatment as compared to the acellular tissue matrix from which the hydrogel is formed.
1 more element
Dependencies are inferred from the claim text.