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US 10,092,599 B2Granted
Methods for enhancing hematopoietic stem/progenitor cell engraftment
AssigneeChildren's Medical Center Corporation
InventorsLeonard I. Zon, Pulin Li
Life of this patent
Estimating the term…
Abstract
Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
Claims20
A method for enhancing hematopoietic cell engraftment in a subject, the method comprising:
- (a) contacting a population of hematopoietic cells with a compound selected from the group consisting of:
- 1,2-didecanoyl-glycerol (10:0), 1-hexadecyl-2arachidonoyl glycerol, 6-formylindolo [3,2-B] carbazole, anandamide, carbacyclin, carbamyl PAF (C-PAF), Prostaglandin B2, 5-hydroxydecanoate, and 1,2-dioctanoyl-sn-glycerol (DOG);
- and
- (b) administering treated cells from step (a) to a subject in need thereof, wherein the engraftment of the hematopoietic cells treated with the compound is increased compared to engraftment of a population of untreated hematopoietic cells.
1 more element
A method for enhancing hematopoietic cell engraftment in a subject comprising:
- administering to a subject following transplantation of a population of hematopoietic cells, a therapeutically effective amount of a compound selected from the group consisting of:
- 1,2-didecanoyl-glycerol (10:0), 1-hexadecyl-2arachidonoyl glycerol, 6-formylindolo [3,2-B] carbazole, anandamide, carbacyclin, carbamyl PAF (C-PAF), Prostaglandin B2, 5-hydroxydecanoate, and 1,2-dioctanoyl-sn-glycerol (DOG);
- and
- wherein the level of engraftment of the hematopoietic cells in the subject treated with the compound is increased compared to engraftment of a population of hematopoietic cells in an untreated subject.
1 more element
Dependencies are inferred from the claim text.