Antiviral composition containing material involved in phosphatidylcholine synthesis pathway

#The present invention relates to a composition for inhibiting viral proliferation, comprising at least one substance involved in phosphatidylcholine synthesis pathway, a pharmaceutical composition for preventing or treating viral diseases comprising the same, and a health functional food composition, a quasi-drug composition, and a feed composition for preventing or ameliorating viral diseases.

#Picornavirus is a positive single-stranded RNA virus with 7.2 Kb to 8.5 Kb, in which an RNA genome is only 7500 nt long. In addition, the virus is a very small globular non-enveloped virus with a size of approximately 22 nm to 30 nm, and is the oldest known virus. Rhinovirus, enterovirus, cardiovirus, aphthovirus, hepatovirus, etc. belong to picornavirus.

#At least 50% of cold-inducing pathogenic viruses are rhinovirus. However, therapeutic agents against rhinovirus infection have not yet been developed. As drugs that inhibit rhinoviruses, tremacamra (Turner R B et al., 1999, JAMA 281:1797-1804) which is a drug inhibiting rhinoviruses to be bound to ICAM-1, a receptor, in the form of sICAM-1, and a drug (Wang, Q M, 2001. Prog. drug Res. 229-253; Chen D H et al., 2003. Bioorg Med Chem Lett 13:3531-3536.; Dragovich P S et al., 2002. J Med Chem 45:1607-1623) which has a function to inhibit rhinovirus (HRV) 3C protease have been reported.

#FIG. 1 shows a series of schematic illustration in which human rhinovirus induces host cell necrosis so that progeny virus is released therefrom to induce a cold.

#FIG. 2 shows an action mechanism of substances involved in phosphatidylcholine synthesis pathway of the present invention.

#FIG. 3 shows an effect of inhibiting proliferation of rhinovirus type 2 according to the concentration of substances involved in the phosphatidylcholine synthesis pathway.

#In one aspect for achieving the above objects, the present invention provides an antiviral composition comprising at least one substance involved in phosphatidylcholine synthesis pathway.

#The substance involved in the phosphatidylcholine synthesis pathway refers to choline, phosphocholine, cytidine triphosphate, CDP-choline, phosphorylcholine, or phosphatidylcholine.

#Choline is changed to phosphocholine by choline kinase under the influence of adenosine triphosphate (ATP). Meanwhile, cytidine, a type of nucleoside, is changed to cytidine triphosphate (CTP) by phosphorylation. CDP-choline is formed when cytidine triphosphate is added to phosphocholine (A. L.Henneberry and three others, 2001. Mole. Bioliology of the Cell 12:511-520p). Phosphatidylcholine is formed when diacylglycerol is added to CDP-choline.