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US 10,092,580 B2Granted
Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Benedikt Vollrath, Sergio G. Duron, Carl Lebel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Andrew M. Trammel, Michael Christopher Scaife, Jeffrey P. Harris
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Abstract
Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
Claims3
A sterile otic composition comprising
- (i) a thermoreversible gel comprising from about 14% to about 17% of a copolymer of polyoxyethylene and polyoxypropylene by weight of the composition;
- and
- (ii) from about 0.01% to about 20% of a multiparticulate non-microencapsulated bisphosphonate by weight of the composition;
- wherein the average diameter of the multiparticulate non-microencapsulated bisphosphonate is from about 3 μm to about 50 μm;
- and
- wherein the composition provides a sustained release of the bisphosphonate across the round window membrane into the cochlea for a period of at least 5 days after a single administration, and wherein the composition is aqueous and substantially free of co-solvent.
3 more elements
Dependencies are inferred from the claim text.