Gold(I) complexes with anticancer properties and methods of use thereof
AssigneeKing Fahd University of Petroleum and Minerals
InventorsMuhammad Altaf, Muhammad Monim-Ul-Mehboob, Anvarhusein Abdulkadir Isab, Saleh Altuwaijri
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Abstract
Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
Claims5
A method for inhibiting proliferation of prostate cancer cells, comprising:
- contacting the prostate cancer cells with a cytotoxic effective amount of a gold(I) complex represented by Formula (3), wherein Formula (3) is:
Dependencies are inferred from the claim text.