Sterol derivatives for treating neurosensory hearing loss, and corresponding composition

A method for treating hearing in a subject, the method comprising:

• placing a composition in contact with at least part of the cochlea of the ear of a subject, said composition being characterised in that it contains, in a pharmaceutically acceptable vehicle, at least one compound of formula (I):
• in which formula R1═H or R—CO, with R═H, CH3 or C2H5;
• R2═H or OH;
• R3═—NR5R6, R5 being H or —(CH2)3NH2 and R6 being taken from the group formed by —(CH2)4NH2;
• —(CH2)3NH(CH2)4NH2;
• —(CH2)4NH(CH2)3NH2;
• —(CH2)3NH(CH2)4NH(CH2)3NH2;
• —(CH2)3NH2;
• —(CH2)2-imidazol-4-yl and —(CH2)2-indol-3-yl;
• R4═H or OH in position 20, 22, 24, 25, 26 or 27, positioned so as to obtain an asymmetric centre of configuration R or S;
• Z1 and Z2 each represent the number of double bonds between the atoms C7 and C8 and C22 and C23 respectively (either 0 or 1);
• T1, T2 and T3=H or CH3, independently of each other;
• T4=H, CH3, or C2H5, positioned so as to obtain an asymmetric centre of configuration R or S in position 24;
• and/or at least one pharmaceutically acceptable salt of at least one compound of formula (I).