Substituted benzene compounds

A compound of Formula II:

• or a pharmaceutically acceptable salt thereof;
• wherein
• R701 is H, F, OR707, NHR707, —(C≡C)—(CH2)n7—R708, phenyl, 5- or 6-membered heteroaryl, C3-8 cycloalkyl, or 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein the phenyl, 5- or 6-membered heteroaryl, C3-8 cycloalkyl or 4-7 membered heterocycloalkyl each independently is optionally substituted with one or more groups selected from halo, C1-3 alkyl, OH, O—C1-6 alkyl, NH—C1-6 alkyl, and, C1-3 alkyl substituted with C3-8 cycloalkyl or 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein each of the O—C1-6 alkyl and NH—C1-6 alkyl is optionally substituted with hydroxyl, O—C1-3 alkyl or NH—C1-3 alkyl, each of the O—C1-3 alkyl and NH—C1-3 alkyl being optionally further substituted with O—C1-3 alkyl or NH—C1-3 alkyl;
• each of R702 and R703, independently is H, halo, C1-4 alkyl, C1-6 alkoxyl or C6-C10 aryloxy, each optionally substituted with one or more halo;
• R704 is C1-4 alkyl;
• R707 is C1-4 alkyl optionally substituted with one or more groups selected from hydroxyl, C1-4 alkoxy, amino, mono- or di-C1-4 alkylamino, C3-8 cycloalkyl, and 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein the C3-8 cycloalkyl or 4-7 membered heterocycloalkyl each independently is further optionally substituted with C1-3 alkyl;
• R708 is C1-4 alkyl optionally substituted with one or more groups selected from OH, halo, and C1-4 alkoxy, 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, or O—C1-6 alkyl, wherein the 4-7 membered heterocycloalkyl can be optionally further substituted with OH or C1-6 alkyl;
• and
• n7 is 0, 1 or 2.

A compound of Formula VI or VII:

• or a pharmaceutically acceptable salt thereof;
• wherein
• n5 is 0, 1, or 2;
• n6 is 1 or 2;
• R501 is C(H) or N;
• R502, R503, R504 and R505 are, independently for each occurrence, C1-4 alkyl;
• R506 is cyclohexyl substituted by N(C1-4 alkyl)2 or piperidine substituted by 1, 2, or 3 C1-4 alkyl groups;
• when R501 is C(H), R507 is morpholine;
• piperidine;
• diazepane;
• pyrrolidine;
• azetidine;
• O—C1-6 alkyl;
• or O-heterocycle, wherein the heterocycle is a 4-7 membered heterocycle containing an oxygen or nitrogen, or both, and wherein the nitrogen can optionally be substituted with C1-3 alkyl;
• wherein the piperidine, diazepane, pyrrolidine or azetidine groups can be optionally further substituted with OH, C1-6 alkyl, or O—C1-3 alkyl;
• or when R501 is C(H), R507 can be piperazine optionally further substituted with C1-6 alkyl, provided that R506 is piperidine substituted by 1, 2, or 3 C1-4 alkyl groups;
• when R501 is N, R507 is morpholine;
• piperidine;
• piperazine;
• diazepane;
• pyrrolidine;
• azetidine;
• O—C1-6 alkyl;
• or O-heterocycle, wherein the heterocycle is a 4-7 membered heterocycle containing an oxygen or nitrogen, or both, and wherein the nitrogen can optionally be substituted with C1-3 alkyl;
• wherein the piperidine, piperazine, diazepane, pyrrolidine or azetidine groups can be optionally further substituted with OH, C1-6 alkyl, or O—C1-3 alkyl;
• R602 , R603, R604 and R605 are, independently for each occurrence, C1-4 alkyl;
• R606 is cyclohexyl substituted by N(C1-4 alkyl)2 or piperidine substituted by 1, 2, or 3 C1-4 alkyl groups;
• and
• R607 is morpholine, piperidine, piperazine, pyrrolidine, diazepane, azetidine or O—C1-6 alkyl, wherein the piperidine, diazepane or azetidine groups can be optionally further substituted with OH or C1-6 alkyl.