Combinations of AKT inhibitor compounds and chemotherapeutic agents, and methods of use
AssigneeGenentech, Inc.
InventorsKui Lin, Michelle Nannini, Elizabeth Punnoose, Deepak Sampath, Jeffrey Wallin, Premal Patel
Life of this patent
Estimating the term…
Abstract
The invention provides combinations comprising a) compound of formula I: or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
Claims10
A method for treating breast cancer in a human patient in need thereof comprising, administering to the patient a) a therapeutically effective amount of a compound of formula Ia:
- or a pharmaceutically acceptable salt thereof;
- and b) a therapeutically effective amount of paclitaxel, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.