Treatment of proliferative disorders with a chemiluminescent agent

A method of inhibiting proliferation of cancer cells in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound having the general formula:

• wherein:
• X is N;
• Y and Z are each independently O or S;
• R2 is a substituted or non-substituted phenyl;
• and
• R1 and R3 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heteroalicyclic, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro, azide, phosphonyl, phosphinyl, carbonyl, thiocarbonyl, urea, thiourea, O-carbamyl, N-carbamyl, O-thiocathatnyl, N-thiocarbatnyl, C-amido, N-amido, C-carboxy, O-carboxy, sulfonamide, hydrazine and amino, or, alternatively, any two of R1-R4 form a five- or six-membered alicyclic or aromatic ring,
• thereby inhibiting said proliferation of cancer cells,
• wherein the method is devoid of administering a therapeutically effective amount of a photosensitizer in combination with said compound, and
• wherein said cancer cells are selected from the group consisting of angiosarcoma cells, bile duct carcinoma cells, bladder cancer cells, brain cancer cells, breast cancer cells, cervical cancer cells, chondrosarcoma cells, chordoma cells, choriocarcinoma cells, colon cancer cells, embryonal carcinoma cells, ependymoma cells, esophageal carcinoma cells, Ewing's tumor cells, fibrosarcoma cells, hepatic carcinoma cells, kidney cancer cells, leiomyosarcoma cells, liposarcoma cells, lung cancer cells, mesothelioma cells, myxosarcoma cells, osteogenic sarcoma cells, ovarian cancer cells, pancreatic cancer cells, prostate cancer cells, rectal cancer cells, retinoblastoma cells, rhabdomyosarcoma cells, sebaceous gland carcinoma cells, seminoma cells, skin cancer cells, stomach carcinoma cells, synovioma cells, sweat gland carcinoma cells, testicular cancer cells, thyroid cancer cells, tracheal cancer cells and uterine cancer cells.