Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
AssigneePharnext
InventorsDaniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Rodolphe Hajj
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Abstract
The present invention relates to compositions and methods for controlling glycemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies for diabetes and related disorders, based on compositions controlling the blood glucose level.
Claims13
A method for treating diabetes or a related disease selected from impaired glucose tolerance, impaired fasting glucose, insulin resistance, metabolic syndrome, postprandial hyperglycemia and overweight or obesity in a mammalian subject in need thereof, comprising administering to said subject an effective amount of a composition comprising:
- ifenprodil and fenspiride,
- fenspiride and torasemide,
- fenspiride and triamterene, or
- fenspiride and tolfenamic acid,
- or salt(s), prodrug(s), or sustained release formulation(s) thereof.
A method for controlling blood glucose level in a mammalian subject in need thereof, comprising administering to said subject a composition comprising fenspiride, or a salt, prodrug or a sustained release formulation thereof in combination with at least one further compound selected from ifenprodil, torasemide, triamterene, tolfenamic acid, or salt(s), prodrug(s) or sustained release formulation(s) thereof.
A method for decreasing insulin resistance in a mammalian subject in need thereof, comprising administering to said subject a composition comprising fenspiride, or a salt, prodrug or a sustained release formulation thereof in combination with at least one further compound selected from ifenprodil, torasemide, triamterene, tolfenamic acid, or salt(s), prodrug(s) or sustained release formulation(s) thereof.
A method for increasing or stimulating glucose uptake in adipocytes or muscular cells in a mammalian subject in need thereof, comprising administering to said subject a composition comprising fenspiride or a salt, prodrug or a sustained release formulation thereof in combination with at least one further compound selected from ifenprodil, torasemide, triamterene, tolfenamic acid, or salt(s), prodrug(s) or sustained release formulation(s) thereof.
Dependencies are inferred from the claim text.