Spiro-thiazolones

A compound of formula I,

• wherein
• X1 C—R1 or N;
• X2 C—R1 or N;
• X3 C—R1 or N;
• X4 C—R1 or N;
• whereby
• i) one of X1, X2, X3 is C—R1 and X4 is N,
• ii) each of X1, X2, X3 and X4 is C—R1;
• R1 each separately is selected from the group consisting of hydrogen, halogen, hydroxy, C1-6-alkyl and C1-6-alkoxy;
• R2 is selected from the group consisting of hydrogen and C1-6-alkyl;
• R3 is selected from the group consisting of hydrogen and C1-6-alkyl;
• or R2 and R3 together are ═O;
• R4 is hydrogen;
• R5 is selected from the group consisting of
• i) hydrogen,
• ii) C3-7-cycloalkyl,
• iii) C3-7-cycloalkyl substituted by one or more substituents individually selected from halogen and C1-6-alkyl,
• iv) C1-6-alkyl,
• v) C1-6-alkyl substituted by one or more substituents individually selected from amino, halogen, hydroxy, C1-6-alkoxy, —O—C(═O)—C1-6-alkyl, NH(C═O)O—C1-6-alkyl and —O—Si(C1-6-alkyl)3,
• vi) aryl,
• vii) aryl substituted by one or more substituents individually selected from halogen and C1-6-alkyl,
• viii) heteroaryl, and
• ix) heteroaryl substituted by one or more substituents individually selected from halogen and C1-6-alkyl;
• R6 is selected from the group consisting of
• i) C1-6-alkyl,
• ii) C1-6-alkyl substituted by one or more substituents individually selected from amino, halogen, C1-6-alkoxy, —O—C(═O)C1-6-alkyl, N(C1-6-alkyl)2, NH(C═O)O—C1-6-alkyl, SO2—C1-6-alkyl and —O—Si(C1-6-alkyl)3;
• iii) C2-6-alkenyl
• iv) aryl,
• v) aryl substituted by one or more substituents individually selected from halogen and C1-6-alkyl;
• vi) C3-9-cycloalkyl,
• vii) C3-9-cycloalkyl substituted by one or more substituents individually selected from —(C═O)O—C1-6-alkyl, oxo, C1-6-alkoxy and C1-6-alkyl;
• viii) heterocyclyl,
• ix) heteroaryl, and
• x) heteroaryl substituted by one or more substituents individually selected from halogen, C1-6-alkoxy and C1-6-alkyl;
• or R5 and R6 together are selected from the group consisting of
• i) C3-9-cycloalkyl, optionally fused with one or two phenyl,
• ii) C3-9-cycloalkyl, optionally fused with phenyl, wherein the phenyl moiety is substituted by one or more substituents individually selected from halogen, hydroxy, (C═O)O—C1-6-alkyl, C1-6-alkoxy and C1-6-alkyl,
• iii) C3-6-cycloalkenyl,
• iv) heterocyclyl, optionally fused with one or two phenyl, and
• v) heterocyclyl, optionally fused with phenyl, wherein the heterocyclyl moiety is substituted by one or more substituents individually selected from oxo, (C═O)O—C1-6-alkyl and SO2—C1-6-alkyl or wherein the phenyl moiety is substituted by one or more halogen;
• R7 is hydrogen;
• or R4 and R7 together are —(CH2)n—;
• and
• n is 2, 3 or 4;
• or pharmaceutically acceptable salts thereof.