Methods of modulation of branched chain acids and uses thereof
AssigneeBaylor College of Medicine
InventorBrendan Lee
Life of this patent
Estimating the term…
Abstract
A method of modulating plasma levels of branched chain amino acids and branched chain alpha-keto acids is disclosed, wherein an ammonia scavenger compound or a salt thereof, for example phenylbutyrate or an even numbered congener thereof or a salt thereof, is administered to an individual in need thereof. In various methods, a decrease in plasma levels of branched chain amino acids and branched chain alpha-keto acids is effected to treat individuals suffering from an inborn error in metabolism of amino acids, such as Maple Syrup Urine Disease, for example.
Claims11
A method of treating an individual for maple syrup urine disease (MSUD), comprising the step of administering a therapeutically effective amount of sodium phenylbutyrate to the individual.
A method of reducing high plasma levels of branched chain amino acids in an individual, comprising the step of administering a therapeutically effective amount of sodium phenylbutyrate to the individual, wherein the high plasma levels of branched chain amino acids is compared to levels of branched chain amino acids in a healthy individual.
Dependencies are inferred from the claim text.