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AssigneeAlpina Laudanum Institute of Phytopharmaceutical Sciences AG
InventorDana Daneshvari
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The invention relates to a wet granulation process comprising contacting a material to be granulated with a granulating liquid, wherein the granulating liquid comprises Arabic gum. The process may be used for improving dissolution kinetics of the material to the granulated, for example, of Arabic gum and/or metal salts, such as organic metal salts. Furthermore, the invention relates to a granulate material comprising Arabic gum, wherein the individual granules making up the granulate material are porous, preferably exhibiting a mean porosity of between about 15% to about 75%, which are obtainable by the process according to the present invention. The invention also provides a composition comprising the granulate material, for example, for the preparation of a liquid, such as a beverage, and the granulate material and the composition of the present invention for use as a medicament and/or as a dietary supplement.
A wet granulation process preparing granules comprising contacting a material to be granulated with a granulating liquid, wherein the granulating liquid comprises Arabic gum and the concentration of Arabic gum in the granulating liquid is from about 5% to about 40% (w/v) and wherein the material to be granulated is Arabic gum or one or more metal salts where the metal is selected from the group consisting of potassium, sodium, lithium, calcium, magnesium, zinc, selenium, and iron, and wherein the counter ion of the metal salt is an organic counter ion selected from the group consisting of acetate, alginate, ascorbate, aspartate, amygdalate, benzoate, borogluconate, carbasalate, citrate, cyclamate, dinatriumtetralactate, dobesilate, ferro-phospholactate, folinate, formate, fumarate, glubionate, glucoheptonate, gluconate, glutamate, glycerophosphate, iopodate, ketoglutarate, lactate, lactogluconate, laevulinate, malate, methionate, orotate, oxalate, pangamate, pantothenate, phospholactate, phatalate, picrate, pidolate, propionate, resinate, saccharate (glucarate), saccharin, sorbate, and succinate;
Dependencies are inferred from the claim text.
From the US filing history. Foreign family members aren’t listed.
Processes: resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Of vegetable origin: exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
Using additives: inorganic salts, minerals or trace elements
Shaping or working of foodstuffs characterised by the products: agglomerating; Granulating; Tabletting
About 7 years 5 months of term left · ends 30 Mar 2034 (estimated)
This application is a national stage application (under 35 U.S.C. § 371) of PCT/EP2013/001055, filed Apr. 10, 2013, which claims benefit of European Application No. 12002533.3, filed Apr. 10, 2012, both of which are incorporated herein by reference in their entirety.
The present invention relates to a wet granulation process for producing granulate material comprising Arabic gum and such granulate material which exhibits improved go solubility characteristics.
Arabic gum, also known as gum Arabic, acacia gum, chaar gund, char goond, or meska, is a natural gum made of hardened sap taken from acacia trees. Arabic gum, which is edible and exhibits glue-like characteristics, essentially consists of a branched long-chain polysaccharide (made up of L-arabinose, D-galactose, L-rhamnose and D-glucuronic acid) and alkaline earth metal and alkali metal salts. Arabic gum is primarily used in the food industry, e.g. as stabilizer, emulsifying or thickening agent, and is an important ingredient, for example, in soft drink syrups and “hard” gummy candies such as gumdrops or marshmallows. Furthermore, it is used as a binder, emulsifying or viscosity increasing agent in pharmaceutical and cosmetic compositions. It is also a key ingredient in traditional lithography and is used in printing, paint production (e.g. as binder in watercolor paint), glue (e.g. on postage stamps, envelopes and cigarette papers), and various industrial applications, including viscosity control in inks and in textile industries. It is an important ingredient in shoe polish and is used as a binder in pyrotechnique compositions.
FIG. 1 shows an electron micrograph of a granulate material according to the present invention consisting of Arabic gum and calcium lactate (about 86% Arabic gum). The upper panel represents a 200× magnification, scale bar=500 μm. The lower panel represents a 500× magnification, scale bar=200 μm.
FIG. 2 shows an electron micrograph of a granulate material according to the present invention consisting of Arabic gum and calcium glutamate (about 82% Arabic gum). The upper panel represents a 200× magnification, scale bar=500 μm. The lower panel represents a 500× magnification, scale bar=200 μm.
FIG. 3 shows an electron micrograph of a granulate material according to the present invention consisting of Arabic gum and magnesium lactate (about 84% Arabic gum). The upper panel represents a 200× magnification, scale bar=500 μm. The lower panel represents a 500× magnification, scale bar=200 μm.
In a first aspect, the present invention provides a wet granulation process comprising contacting a material to be granulated with a granulating fluid, wherein the granulating fluid comprises Arabic gum. The state of matter of the granulating fluid is preferably liquid at room temperature, e.g. at about 20° C. to about 45° C. Thus, the granulating fluid is preferably a granulating liquid.
The concentration of Arabic gum in the granulating liquid is preferably between about 5% and about 40% (w/v), preferably between about 15% and about 35% (w/v), more preferably between about 20% and about 30% (w/v), even more preferably between about 22% and about 28% (w/v), and most preferably the concentration of Arabic gum in the granulating liquid is about 25% (w/v).
Preferably, the granulating liquid does not comprise honey solution and/or tricalcium phosphate.