Controlled-release floating pharmaceutical compositions
AssigneeFlamel Ireland Limited
InventorsCatherine Castan, Philippe Caisse
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Abstract
The invention relates to a pharmaceutical composition comprising a plurality of controlled-release coated microparticles each comprising a floating core, on the surface of which is deposited a layer containing at least one active principle, said layer being covered with a controlled-release coating, characterized by the fact that said floating core is composed of cellulose acetate phthalate and has an apparent density of less than or equal to 0.6 g/mL and said coated microparticles have a density of less than or equal to 0.7 g/mL.
Claims23
A controlled-release coated microparticle comprising:
- a floating core, wherein said floating core comprises cellulose acetate phthalate, and wherein said floating core has an apparent density of less than or equal to 0.6 g/mL and said floating core comprises closed pores;
- an active ingredient layer deposited on said floating core;
- and
- a controlled-release coating covering said active ingredient layer;
- and
- wherein said coated microparticle has an apparent density of less than or equal to 0.7 g/mL.
A controlled-release coated microparticle comprising:
- a floating core comprising closed pores,
- an active ingredient layer deposited on the surface of said floating core,
- a controlled-release coating covering said active ingredient layer;
- wherein said core is composed of cellulose acetate phthalate.
Dependencies are inferred from the claim text.