Hypotonic microbicidal formulations and methods of use
AssigneeThe Johns Hopkins University
InventorsKatharina Maisel, Craig W. Hendrix, Laura Ensign, Edward Fuchs, Richard Cone, Justin Hanes
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Abstract
Hypotonic microbicidal compositions including an antimicrobial, such as an antiviral compound, and a pharmaceutically acceptable carrier in a solution formulation having hypotonic osmolarity have been developed for administration rectally to the gastrointestinal mucosa. In a preferred embodiment for use in preventing or decreasing HIV infection, the microbiocidal is tenofovir, or a prodrug or derivative thereof. The formulations may include additional agents such as surfactants to enhance cleansing, buffers, or preservatives. Polymers may be included for osmolarity as well as comfort.
Claims17
A hypotonic microbicidal composition comprising
- an effective amount of a microbiocide as a free drug to inhibit infection or replication, and
- a pharmaceutically acceptable carrier suitable for administration rectally or vaginally having an osmolarity between 50 and 280 mOsm comprising hydrogel forming polymer that undergoes sol-gel transitions when at or above a critical gelling concentration (CGC) and at or above the critical gelling temperature at or below 37° C.
Dependencies are inferred from the claim text.