Use of a composition comprising avocado perseose in the protection of epidermal stem cells

A method for treating skin cancer, consisting essentially of administering to a subject in need thereof an effective amount of a composition consisting essentially of at least one C7 sugar or derivative of the following formula (I)

• and one additional active agent;
• wherein
• Ra is a hydrogen atom and Rb is an —OR2 or CRaRb represents the CO radical;
• R1, R2, R3, R4, R5, R6 and R7 are, independently of one another
• a hydrogen atom or
• a —(CO)—R radical in which R is a saturated or unsaturated hydrocarbon chain containing from 11 to 24 carbon atoms, optionally substituted by one or more substituents selected from the group consisting of hydroxy radicals (—OH), ethoxy radicals (—OC2H5) and the —SO3M group, wherein M is a hydrogen atom, an ammonium ion (NH4+) or a metal ion;
• or
• a —(CO)—R′ radical in which R′ is a saturated or unsaturated hydrocarbon chain containing from 2 to 10 carbon atoms, optionally substituted by one or more substituents selected from the group consisting of hydroxy radicals (—OH), ethoxy radicals (—OC2H5) and the —SO3M group, wherein M is a hydrogen atom, an ammonium ion (NH4+) or a metal ion;
• wherein at least one of the hydroxyl groups is esterified;
• and a pharmaceutically acceptable excipient, wherein said composition protects epidermal stem cells,
• wherein said stem cells are basal stem cells,
• wherein said subject is a child, and
• wherein said additional active agent is:
• a dermatological active agent selected from the group consisting of emollients, moisturizing active agents, keratin synthesis activators, keratoregulators, keratolytics, agents that repair the cutaneous barrier, peroxisome proliferator-activated receptor (PPAR) agonists, RXR or LXR agonists, scarring agents, sebum-regulating agents, anti-irritation agents, soothing agents, anti-inflammatory agents, antioxidant agents and anti-aging agents, depigmenting or hypodepigmenting agents, pigmenting agents, lipolytic agents or lipogenesis inhibitors or anti-cellulitis or slimming agents, organic or inorganic sun screens or filters, antifungal compounds, preservatives, antibacterial agents, prebiotics and probiotics, antibiotics, immunomodulators and mixtures thereof;
• selected from the group consisting of prebiotics and probiotics, antibacterial agents, antifungal compounds, preservatives, immunomodulators, growth factors, and mineral or organic sun filters or screens (pigmentary or ultrafine);
• selected from the group consisting of wound-healing agents and/or agents that repair the cutaneous barrier, anti-inflammatory and/or anti-irritations and/or soothing agents, sebum-regulating agents, anti-inflammatory and/or anti-irritations and/or soothing agents, hypopigmenting or depigmenting agents, inorganic or organic sun filters and screens, and preservatives;
• selected from the group consisting of plant oils, oleodistillates or concentrates of plant or animal oil, unsaponifiables of plants or plant oil, peptides or complexes of plant amino acids, butyl avocadate, extracts rich in polyphenols, lupeol, Cupuacu butter, oxazolines, and mixtures thereof;
• or
• selected from the group consisting of diethyl pyridine-2,4-dicarboxylate, sodium cocoyl alaninate, pentapeptide-31, ctyldodecanol, Echium Planta-gineum Seed Oil, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Helianthus Annuus Sunflower Seed Oil Unsaponifiables, Helianthus Annuus Sunflower Seed Oil, Ethyl Ferulate, Polyglyceryl-5 Trioleate, Rosmarinus Officinalis Leaf Extract, Aqua, Disodium Uridine Phosphate, hydrolyzed alginic acid, extracts of Laminaria digitata, extracts of plant stem cells of Apline rose, extracts of plant stem cells of Gamay Freaux teinturier grape, extracts of plant stem cells of Uttwiler spatlauber apple (Malus domestica), extracts of plant stem cells of argan, extracts of plant stem cells of Vitis vinifera vines, and plant stem cells of Christe Marine shoots.