Method of making implantable medical devices having controlled surface properties
AssigneeVactronix Scientific, LLC
InventorsJulio C. Palmaz, Eugene A. Sprague, Christopher E. Banas
Life of this patent
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Abstract
An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at the blood flow surface of the stent.
Claims20
A method for controlling surface properties of an implantable medical device, comprising:
- vacuum depositing a device forming biomaterial selected from one of elemental nickel and elemental titanium or nickel-titanium alloy onto a cylindrical substrate maintained at a temperature range between about 300 to 1100 degrees Centigrade, the substrate having a pre-determined pattern of recesses in an outer surface thereof to form a tubular device forming biomaterial on the cylindrical substrate;
- controlling the formation of heterogeneities at a blood or tissue contacting surface of the tubular device forming biomaterial during the vacuum depositing step, such that controlled heterogeneities are formed at the blood or tissue contacting surface;
- and
- removing the medical device from the substrate.
A method for controlling surface properties of an implantable medical device, comprising:
- forming a tubular nickel-titanium alloy biomaterial onto a substrate maintained at a temperature range between about 300 to 1100 degrees Centigrade and non-zero bias voltage present between about −1000 and +1000 volts applied to the generally cylindrical substrate sufficient to impart a hyperthermal energy of energetic species arriving at the surface of the substrate to between about 0.1 eV and about 700 eV, the substrate having a pre-determined pattern of topographical features on an exterior surface thereof, wherein the pattern of topographical features comprises a positive or negative pattern that is imparted to the device forming biomaterial;
- controlling the formation of heterogeneities at a blood or tissue contacting surface of the biomaterial by fabricating the bulk material of the medical device to have a defined grain sizes that yield sites along the surface of the medical device having protein binding capability, wherein the controlled heterogeneities have a blood contact surface of diameter less than or equal to about 10 μm and an inter-heterogeneity boundary between about 0 and 2 μm;
- and
- removing the medical device from the substrate.
A method for controlling surface properties of an implantable medical device, comprising:
- vacuum depositing a generally tubular nickel-titanium alloy device onto a substrate, the substrate having a pre-determined pattern of recesses and the substrate is maintained at a non-zero bias voltage present between about −1000 and +1000 volts applied to the generally cylindrical substrate sufficient to impart a hyperthermal energy of energetic species arriving at the surface of the substrate to between about 0.1 eV and about 700 eV;
- controlling the formation of heterogeneities at a blood or tissue contacting surface of the biomaterial during fabrication of the medical device, such that controlled heterogeneities are formed and have a substantially homogeneous surface energy and electrostatic charge across a blood contact surface of the metal film, wherein the controlled heterogeneities have a blood contact surface of diameter less than or equal to about 10 μm and an inter-heterogeneity boundary between about 0 and 2 μm;
- and
- removing the medical device from the substrate.
Dependencies are inferred from the claim text.