Trans-endoscopic and laparoscopic surgery port

A surgical access port comprising:

• a cannula comprising a first end and a second end, wherein the first end is insertable into a target site, the cannula defining a passageway for introduction of one or more surgical instruments;
• at least one retainer outwardly extending circumferentially about the first end of the cannula, the at least one retainer having an inner retainer diameter, wherein the retainer is adapted to engage an inside surface of the target site when the first end of the cannula is inserted into the target site;
• and
• an elongate receptacle having a mating end for matingly engaging the second end of the cannula;
• and
• a self-sealable, pliable, and passage-way enclosing dome extending from the receptacle at an end opposite from the mating end, the dome comprising a self-sealable material through which one or more surgical instruments are directly insertable at multiple insertion locations, the dome having an inner diameter at its widest point greater than the inner retainer diameter and a manipulation area permitting angular or pivotal ranges of movement for the one or more surgical instruments within the manipulation area, and the dome sealingly engageable with the one or more surgical instruments introduced therethrough and self-sealable to form a zero seal at the multiple insertion locations when the one or more surgical instruments are removed.