Pathogen-resistant animals having modified CD163 genes
AssigneeThe Curators of the University of Missouri
InventorsRandall S. Prather, Kevin D. Wells, Kristin M. Whitworth
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Abstract
Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The animals and offspring have chromosomal modifications of a CD163 gene. The invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.
Claims36
A porcine animal or offspring thereof or a porcine cell comprising a modified chromosomal sequence in at least one allele of a gene encoding a CD163 protein, wherein the modified chromosomal sequence in the at least one allele comprises a deletion and the deletion consists of
- an 11 base pair deletion from nucleotide 3,137 to nucleotide 3,147 as compared to reference sequence SEQ ID NO:
- 47.
Dependencies are inferred from the claim text.