US 10,088,459 B2Granted

Liquid mixing device, and liquid chromatography apparatus

AssigneeHitachi High-Technologies Corporation

InventorsYugo Onoda, Shoji Tomida, Kouichi Sugimoto, Takashi Yagi, Tetsuya Watanabe

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Abstract

A liquid-mixing device that minimizes solvent leakage and reduces creep of or damage to the component parts of said liquid-mixing device even at ultrahigh pressures of 100 MPa and up. Also, a liquid chromatography device using said liquid-mixing device. Said liquid chromatography device is provided with a supply pump that supplies a plurality of different solutions, a liquid-mixing device that mixes the supplied solutions, a sample injection device that injects a sample into the mixture of solutions, a column that separates the components of the injected sample, and a detector that detects the separated components. The liquid-mixing device has an inlet-side connector through which the plurality of different solutions flow in, a liquid-mixing section in which said solutions are mixed, and an outflow-side connector through which the mixed solutions flow out. The inlet-side connector and the liquid-mixing section are directly bonded to each other via diffusion bonding, as are the liquid-mixing section and the exit-side connector.

Claims6

Dependent claims

A liquid chromatography apparatus, comprising:

a feed pump configured to feed a plurality of solutions;
a liquid mixing device configured to mix the solutions fed by the feed pump;
a sample injection device configured to inject a sample in the solutions mixed in the liquid mixing device;
a column configured to separate components of the sample injected by the sample injection device;
and
a detector configured to detect the components separated in the column, wherein:
the liquid mixing device includes an inlet side connector portion having, on a first axial end thereof, a first hollow shape that allows a first pipe to be connected to the feed pump so that the plurality of solutions fed by the feed pump flow into the inlet side connector portion, a liquid mixing portion configured to mix the solutions that have flowed into the inlet side connector portion, and an outlet side connector portion having, on a first axial end thereof, a second hollow shape that allows a second pipe to be connected to the sample injection device so that the solutions mixed in the liquid mixing portion flow into the sample injection device;
a second axial end of the inlet side connector portion that is opposite to the first axial end of the inlet side connector portion is directly diffusion bonded to the liquid mixing portion;
a second axial end of the outlet side connector portion that is opposite to the first axial end of the outlet side connector portion is directly diffusion bonded to the liquid mixing portion,
the first hollow shape and the second hollow shape are disposed on opposite sides of an imaginary line passing through a center of the inlet side connector portion and the outlet side connector portion,
the liquid mixing portion includes a plurality of laminated structures arranged one behind the other from a region of the liquid mixing portion adjacent to the first hollow shape to a region of the liquid mixing portion adjacent to the second hollow shape, and
a groove shape of the liquid mixing portion includes a spider-web shape and at least another shape selected from the group consisting of a swirl, a plus sign, and a square.

9 more elements

A liquid chromatography apparatus, comprising:

a liquid mixing device configured to mix a plurality of solutions;
a feed pump configured to feed the solutions mixed in the liquid mixing device;
a sample injection device configured to inject a sample in the solutions fed by the feed pump;
a column configured to separate components of the sample injected by the sample injection device;
and
a detector configured to detect the components separated in the column, wherein:
the liquid mixing device includes an inlet side connector portion having, on a first axial end thereof, a first hollow shape that allows a first pipe to be connected to the plurality of solutions so that the plurality of solutions flow into the inlet side connector portion, a liquid mixing portion configured to mix the solutions that have flowed into the inlet side connector portion, and an outlet side connector portion having, on a first axial end thereof, a second hollow shape that allows a second pipe to be connected to the feed pump so that the solutions mixed in the liquid mixing portion flow into the feed pump;
a second axial end of the inlet side connector portion that is opposite to the first axial end of the inlet side connector portion is directly diffusion bonded to the liquid mixing portion;
a second axial end of the outlet side connector portion that is opposite to the first axial end of the outlet side connector portion is directly diffusion bonded to the liquid mixing portion,
the first hollow shape and the second hollow shape are disposed on opposite sides of an imaginary line passing through a center of the inlet side connector portion and the outlet side connector portion,
the liquid mixing portion includes a plurality of laminated structures arranged one behind the other from a region of the liquid mixing portion adjacent to the first hollow shape to a region of the liquid mixing portion adjacent to the second hollow shape, and
a groove shape of the liquid mixing portion includes a spider-web shape and at least another shape selected from the group consisting of a swirl, a plus sign, and a square.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/028,492Filed 19 Dec 2014
Priority: JP 2014-0020789 Jan 2014
Published: US 2016/0266078 A115 Sep 2016
Granted: 2 Oct 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

G01N 30/34
Control of physical parameters of the fluid carrier: of fluid composition, e.g. gradient
B01D 15/12
Characterised by constructional or operational features: relating to the preparation of the feed
B01F 25/431
Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction: straight mixing tubes with baffles or obstructions that…
B01F 25/4416
Characterised by the configuration of the surfaces forming the slits: the opposed surfaces being provided with grooves