Methods and compositions to inhibit metastasis and to treat fibrosis and to enhance wound healing
AssigneeAlbert Einstein College of Medicine
InventorDavid Sharp
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Abstract
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.
Claims18
A method of treating metastasis or inhibiting metastasis in a subject having anaplastic thyroid carcinoma or large lung cell cancer or osteosarcoma comprising administering to the subject an amount of an inhibitor of CEP192 effective to treat metastasis or inhibit metastasis of anaplastic thyroid carcinoma or large lung cell cancer or osteosarcoma, respectively, wherein the inhibitor of CEP192 is a siRNA directed to CEP192 or a shRNA directed to CEP192.
A method of treating fibrosis or scarring, or inhibiting fibrosis or scarring, in a subject comprising administering to the subject an amount of an inhibitor of CEP192 effective to treat fibrosis or scarring, or inhibit fibrosis or scarring, wherein the inhibitor of CEP192 is a siRNA directed to CEP192 or a shRNA directed to CEP192.
A method of treating pain associated with wound healing in a subject having a wound comprising administering to the subject an amount of an inhibitor of CEP192 effective to treat pain associated with wound healing, wherein the inhibitor of CEP192 is a siRNA directed to CEP192 or a shRNA directed to CEP192.
Dependencies are inferred from the claim text.