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US 10,086,105 B2Granted
Chitosan foam medical devices and methods
AssigneeProvidence Health System-Oregon
InventorsJian Xin Guo, Kenton W. Gregory
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Abstract
The invention provides a solid foam wound dressing useful for hemorrhage control and wound repair, as well as methods for making such a wound dressing.
Claims22
A method of making a solid foam wound dressing, consisting essentially of:
- (I) introducing gas bubbles into an aqueous solution to form an aqueous foam with uniformly distributed gas bubbles therein, wherein the aqueous solution comprises chitosan, at least one protic acid, and at least one surface active agent;
- (II) freezing the aqueous foam prepared in step (I) to form a frozen foam at a pressure of between about 100 mTorr to about 750 Torr before the gas bubbles collapse or coalesce and to expand the gas bubbles in the aqueous foam;
- and
- (III) dehydrating the frozen foam to form a solid foam with a uniform structure from bottom to top as well as from side to side,
- wherein step (II) occurs immediately after step (I).
2 more elements
A method of making a solid foam wound dressing, consisting essentially of:
- (I) introducing gas bubbles into an aqueous solution to form an aqueous foam, wherein the aqueous solution comprises chitosan, at least one protic acid and at least one surface active agent;
- (II) freezing the aqueous foam prepared in step (I) to form a frozen foam at a pressure of between about 100 mTorr to about 750 Torr before the gas bubbles collapse or coalesce and to expand the gas bubbles in the aqueous foam;
- and
- (III) dehydrating the frozen foam to form a solid foam, wherein step (II) occurs immediately after step (I).
1 more element
Dependencies are inferred from the claim text.