Rod-shaped plant virus nanoparticles as imaging agent platforms
AssigneeCase Western Reserve University
InventorsNicole Steinmetz, Michael Bruckman
Life of this patent
Estimating the term…
Abstract
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
Claims18
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface of the virus, wherein the virus has a longitudinal relaxivity of greater than about 10 mM−1S−1 per linked imaging agent at 60 mHz.
A method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of a rod-shaped plant virus particle having an imaging agent linked to an interior and/or exterior surface of the virus particle, and generating an image of the tissue region of the subject to which the rod-shaped plant virus particle has been distributed.
Dependencies are inferred from the claim text.