Combination purified inactivated vaccine for flaviviruses
AssigneeThe United States of America, as represented by the Secretary of the Army, on behalf of the Walter Reed Army Institute of Research
InventorsStephen J. Thomas, Kenneth H. Eckels, Joseph R. Putnak
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Abstract
Immunogenic compositions comprising one or more inactivated dengue viruses and one or more inactivated non-dengue flaviviruses and methods of making and using thereof are provided.
Claims20
An immunogenic composition comprising one or more inactivated dengue viruses and one or more inactivated non-dengue flaviviruses, an adjuvant, and a pharmaceutically acceptable vehicle, wherein said non-dengue flaviviruses are selected from the group consisting of yellow fever virus (YFV) group viruses, Japanese encephalitis virus (JEV) group viruses, and Zika virus (ZIKV).
An immunogenic composition comprising an inactivated DENV-1, an inactivated DENV-2, an inactivated DENV-3, an inactivated DENV-4, and one or more inactivated non-dengue flaviviruses selected from the group consisting of yellow fever virus (YFV) group viruses and Japanese encephalitis virus (JEV) group viruses, an adjuvant, and a pharmaceutically acceptable vehicle, wherein the inactivated dengue viruses and the one or more inactivated non-dengue flaviviruses do not result in immunologic interference when administered to a subject.
Dependencies are inferred from the claim text.